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What are the signs and symptoms of inhibitors?

A person with haemophilia who develops inhibitors does not get better after standard treatment with factor concentrates. Inhibitors are suspected when the person, family members, or medical staff notice that treatment is less effective than it used to be. Signs and symptoms of inhibitors include:

  • A bleed is not promptly controlled with the usual dose of factor concentrates.
  • Normal treatment seems less and less effective.
  • Bleeding is more and more difficult to control.

A diagnosis based on signs and symptoms of inhibitors should be confirmed by repeated laboratory tests. Sometimes, inhibitors are discovered during a routine laboratory test.